Polylactic Acid Microspheres Labeled with 166Ho. An alternative to 90Y in the Treatment of Hepatic Carcinoma by Radioembolization

Authors

  • Alejandro Pérez-Doñate Unidad de Investigación de Radiofarmacia y Estabilidad de Medicamentos. Departamento de Química Física, Facultad de Farmacia. Universitat de València.
  • Facundo Pérez-Giménez Unidad de Investigación de Radiofarmacia y Estabilidad de Medicamentos. Departamento de Química Física, Facultad de Farmacia. Universitat de València.
  • Mónica Romero-Otero Unidad de Radiofarmacia. Hospital Clínico Universitario de Valencia.
  • Virginia Pérez-Doñate Servicio de Microbiología. Hospital Universitario de la Ribera, Alzira (Valencia).
  • Juan Alberto Castillo-Garit Unidad de Toxicología Experimental. Universidad de Ciencias Médicas de Villa Clara. Santa Clara (Cuba).

DOI:

https://doi.org/10.46583/nereis_2021.13.785

Keywords:

Holmium-166 microspheres, hepatic radioembolization, Holmium-166, hepatocarcinoma treatment.

Abstract

Liver tumors are an important health problem worldwide that on many occasions is associatedwith previous pathologies and risk factors such as viral hepatitis B and C, excessive alcohol consumptionand the increase in cases of non-alcoholic steatohepatitis, each increasingly relevant inindustrialized countries.In hepatocarcinomas not susceptible to surgical resection, brachytherapy is proving very effectiveagainst systemic and transarterial chemotherapy, developing new minimally invasiveregional treatments with less toxicity.Hepatic radioembolization is a form of brachytherapy consisting in the arterial administrationof microspheres labeled with beta negative emitting radionuclides that have little penetration inliver tissue, allowing the administration of high doses that cause cellular damage in tumor tissue,avoiding the irradiation of the contiguous healthy tissue.Among the most used microspheres are those of resin and/or glass marked with 90Y, althoughthe use of 166Ho on a biodegradable matrix of poly-L-lactic acid is currently increasing, the mainreasons lie in the special characteristics of this radionuclide, such as, lower energy of emissionbeta, shorter half-life as well as the emission of gamma photons, which allows its gammagraphicmonitoring. It is also a paramagnetic element, so it can be detected by means of magnetic resonance,facilitating simulation prior to treatment and its subsequent monitoring.

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Published

2021-11-15