Antioxidant capacity of 5-Fluorouracile and new fluorinated uracil derivates

  • Carlos Casanova Sorní Department of Biomedical Sciences. School of Health Sciences. Universidad Cardenal Herrera-CEU.
  • María Luz Moreno Sancho Department of Basic Sciences. School of Physical Activity and Sport Sciences. Universidad Católica de Valencia San Vicente Mártir.
  • María Miranda Sanz Department of Biomedical Sciences. School of Health Sciences. Universidad Cardenal Herrera-CEU.
  • Inmaculada Almansa Frías Department of Biomedical Sciences. School of Health Sciences. Universidad Cardenal Herrera-CEU.
  • Antonio Falcó Montesinos Department of Biomedical Sciences. School of Health Sciences. Universidad Cardenal Herrera-CEU.
  • María Ángeles Navarro Moreno Department of Basic Sciences. School of Physical Activity and Sport Sciences. Universidad Católica de Valencia San Vicente Mártir.
  • Santos Fustero Lardíes Department of Organic Chemistry. School of Pharmacy. Universitat de València.
  • Salvador Mérida Donoso Department of Biomedical Sciences. School of Health Sciences. Universidad Cardenal Herrera-CEU.
  • Vicente M. Villar Amigó Department of Biomedical Sciences. School of Health Sciences. Universidad Cardenal Herrera-CEU.
Keywords: antioxidants, MDA, lipid peroxidation, antineoplastic, cancer.

Abstract

Oxidative stress is associated with multiple pathologies such as cancer and can exacerbate the development of them. In this work, we have studied the antioxidant capacity of 5-Fluorouracile (5-FU) which is an antineoplastic drug that is used in the treatment of colorectal cancer. 5-FU is a compound that has a chemical structure similar to uracil and is also fluorinated. New fluorinated derivates previously obtained in our laboratory were tested to study its antioxidant activity. All the compounds analyzed were able to inhibit lipid peroxidation when used in concentrations of 10 μM.

Keywords: antioxidants, MDA, lipid peroxidation, antineoplastic, cancer.

Published
2018-05-22