A general procedure is presented to synthesise composite biomaterial systems composed of a porous hydrophobic matrix with a plasma-polymerised hydrophilic coating with applications in tissue engineering. In this work, only two types of composites were synthesized, although this procedure could be used to prepare plenty of materials of this kind. The first type of composite biomaterial has a morphology of polymethyl methacrylate microspheres joined together with interconnected pores from about 10 to 50 ?m. In addition, the second type has the great advantage of being constituted by polycaprolactone, which is a biodegradable hydrophobic polymer matrix. These reabsorbable systems showed a more irregular interconnected porosity with pores in the same range of magnitude. The hydrophilic coating was obtained by plasma polymerization in air after the necessary absorption of 2-hydroxyethyl acrylate vapour on the hydrophobic substrates. The success of the polymerization in the absence of initiator was demonstrated by direct observation through Scanning Electron Microscopy and by weight difference

Keywords: plasma-polymerisation, scanning electron microscopy, policaprolactone, polymethyl methacrylate, poly(2- hydroxyethyl acrylate).